Regular sugar contains about 50 percent fructose, agave has 70 to 90 percent fructose—more than even high fructose corn syrup, a well-known dietary demon. Consuming a high amount of fructose can eventually lead to insulin resistance, according to research in the journal Nutrition & Metabolism, which causes chronically high blood sugar and insulin levels, a problem much worse for you than a temporary hike in blood sugar.

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